Central-edge asymmetry as a probe of Higgs-top coupling in ttˉht\bar{t}h production at LHC

The Higgs-top coupling plays a central role in the hierarchy problem and the vacuum stability of the Standard Model (SM). We propose a central-edge asymmetry ($A_{CE}$) to probe the CP violating Higgs-top coupling in dileptonic channel of $t\bar{t}h(\to b\bar{b})$ production at the LHC. We demonstrate that the CP-violating Higgs-top coupling can affect the central-edge asymmetry through distorting $\Delta y_{\ell^+\ell^-}$ distribution because of the contribution of new top charge asymmetric term. Since $\Delta y_{\ell^+\ell^-}$ distribution is frame-independent and has a good discrimination even in boosted regime, we use the jet substructure technique to enhance the observability of the dileptonic channel of $t\bar{t}h$ production. We find that (1) the significance of dileptonic channel of $t\bar{t}h$ production can reach $5\sigma$ for CP phase $\xi=0,\pi/4,\pi/2$ when the luminosity ${\cal L}=795,993,1276$ fb$^{-1}$ at 14 TeV LHC. (2) the central-edge asymmetry $A_{CE}$ show a good discrimination power of CP phase of $t\bar{t}h$ interaction, which are -40.26\%, -26.60\%, -9.47\% for $\xi=0$, $\pi/4$, $\pi/2$ respectively and are hardly affected by the event selections. Besides, by performing the binned-$\chi^2$ analysis of $\Delta y_{\ell^+\ell^-}$ distribution, we find that the scalar and pseudo-scalar interactions can be distinguished at 95\% C.L. level at 14 TeV HL-LHC.Comment: minor changes, version accepted by PL

An Investigation to Causes and Consequences of IS Operational Misalignment in Chinese SOE Group

IS strategic alignment has consistently been at the forefront of information systems researchers’ and practitioners’ concerns since the seminal paper by Henderson and Venkatraman in 1993. However, scholars have focused more on strategic level alignment. As one of the important perspectives in IS strategic alignment, IS operational alignment are not paid enough attention in the research. This paper investigates operational alignment issues in a Chinese multinational state-owned company. The base research design for the study uses a rigorous Strauss and Corbin grounded theory approach, that consisted of 41 semi-structured interviews in 7 different company branches located in different provinces of China. Based on this study, the IS operational misalignment situations are identified. Furthermore, the causes and consequences of the misalignment situation are further investigated in this Chinese SOE group

Inhibitory Effect of Phthalic Acid on Tyrosinase: The Mixed-Type Inhibition and Docking Simulations

Tyrosinase inhibition studies are needed due to the medicinal applications such as hyperpigmentation. For probing effective inhibitors of tyrosinase, a combination of computational prediction and enzymatic assay via kinetics was important. We predicted the 3D structure of tyrosinase, used a docking algorithm to simulate binding between tyrosinase and phthalic acid (PA), and studied the reversible inhibition of tyrosinase by PA. PA inhibited tyrosinase in a mixed-type manner with a Ki = 65.84 ± 1.10 mM. Measurements of intrinsic and ANS-binding fluorescences showed that PA induced changes in the active site structure via indirect binding. Simulation was successful (binding energies for Dock6.3 = −27.22 and AutoDock4.2 = −0.97 kcal/mol), suggesting that PA interacts with LEU73 residue that is predicted commonly by both programs. The present study suggested that the strategy of predicting tyrosinase inhibition based on hydroxyl groups and orientation may prove useful for screening of potential tyrosinase inhibitors

Strong Decays of the Orbitally Excited Scalar D0∗D^{*}_{0} Mesons

We calculate the two-body strong decays of the orbitally excited scalar mesons $D_0^*(2400)$ and $D_J^*(3000)$ by using the relativistic Bethe-Salpeter (BS) method. $D_J^*(3000)$ was observed recently by the LHCb Collaboration, the quantum number of which has not been determined yet. In this paper, we assume that it is the $0^+(2P)$ state and obtain the transition amplitude by using the PCAC relation, low-energy theorem and effective Lagrangian method. For the $1P$ state, the total widths of $D_0^*(2400)^{0}$ and $D_0^*(2400)^+$ are 226 MeV and 246 MeV, respectively. With the assumption of $0^+(2P)$ state, the widths of $D_J^*(3000)^0$ and $D_J^*(3000)^+$ are both about 131 MeV, which is close to the present experimental data. Therefore, $D_J^*(3000)$ is a strong candidate for the $2^3P_0$ state.Comment: 21 pages, 10 figure

{3,3′-Bis[(anthracen-9-yl)meth­yl]-1,1′-[(ethane-1,2-diyldi­oxy)bis­(ethane-1,2-di­yl)]bis­(imidazol-2-yl­idene)}mercury(II) bis­(hexa­fluoridophosphate) acetonitrile disolvate

In the title compound, [Hg(C42H38N4O2)](PF6)2·2CH3CN, the HgII cation lies on a twofold axis which is also the inter­nal symmetry element of the complete cationic complex. The HgII cation is coordinated by two symmetry-related C(carbene) atoms [Hg—C = 2.058 (9) Å] in a nearly linear geometry, with a C—Hg—C angle of 175.8 (5)°. There are weak inter­molecular C—H⋯F inter­actions in the crystal packing between an F atom of a hexa­fluoridophosphate anion and a –CH2– group of the bis-N-heterocyclic carbene ligand

Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E

Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling technique. After screening and recombination with the prokaryotic non-fusion expression vector pBV220, two lysis plasmids were selected. Among which, a novel mutant E gene (named mE), consisting of a 74-bp non-encoding sequence at 5'-end and a 201-bp gene ΔE, significantly increased the lysis effect on prokaryotic Escherichia coli and Salmonella enteritidis. Moreover, lysis efficiency, as measured by the OD600 value, reached 1.0 (109 CFU), avoiding the bottleneck problem observed with other bacterial lysis procedures, which results in a low concentration of bacteria in suspension, and consequent low production of bacterial ghosts. Our results may provide a promising avenue for the development of bacterial ghost vaccines

Computational Prediction of Protein-Protein Interactions of Human Tyrosinase

The various studies on tyrosinase have recently gained the attention of researchers due to their potential application values and the biological functions. In this study, we predicted the 3D structure of human tyrosinase and simulated the protein-protein interactions between tyrosinase and three binding partners, four and half LIM domains 2 (FHL2), cytochrome b-245 alpha polypeptide (CYBA), and RNA-binding motif protein 9 (RBM9). Our interaction simulations showed significant binding energy scores of −595.3 kcal/mol for FHL2, −859.1 kcal/mol for CYBA, and −821.3 kcal/mol for RBM9. We also investigated the residues of each protein facing toward the predicted site of interaction with tyrosinase. Our computational predictions will be useful for elucidating the protein-protein interactions of tyrosinase and studying its binding mechanisms